Lyles was told that he is no longer an option for one of the Padres' final rotation spots, AJ Cassavell reports.
Lyles (1-5) took the loss to the Giants on Friday, allowing seven runs on 10 hits and one walk while striking out five over 3.2 innings.
Lyles (1-4) took the loss against the Rockies on Friday, giving up four runs on five hits -- including three home runs -- and two walks over six innings while striking out seven.
Lyles (1-2) picked up the win despite allowing four runs on six hits over five innings Friday. He struck out six in a 10-6 win over Arizona.
Lyles will start Friday against the Diamondbacks.
Lyles will start the second game of Saturday's doubleheader against the Dodgers.
Lyles was recalled from Triple-A Albuquerque on Friday, Jeff Sanders of the San Diego Union-Tribune reports.
Lyles, recently released by the Rockies, signed a minor league deal with the Padres on Monday, Jeff Sanders of the San Diego Union-Tribune reports.
Lyles was designated for assignment by the Rockies on Saturday, Thomas Harding of MLB.com reports.
Lyles entered the All-Star break with a 6.34 ERA and a 1.41 WHIP in 38.1 innings pitched this season.